cGMP-binding, cGMP-specific phosphodiesterase materials and methods

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United States of America Patent

SERIAL NO

11315036

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Abstract

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The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.

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Patent Owner(s)

Patent OwnerAddress
ICOS CORPORATIONBOTHELL WA 98021

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Beavo, Joseph A Seattle, WA 20 98
Corbin, Jackie D Nashville, TN 9 58
Ferguson, Kenneth M Bothell, WA 20 67
Francis, Sharron H Nashville, TN 9 58
Kadlecek, Ann Seattle, WA 8 55
Loughney, Kate Seattle, WA 19 78
McAllister-Lucas, Linda M Nashville, TN 8 55
Sonnenburg, William K Mountlake Terrace, WA 18 83
Thomas, Melissa K Boston, MA 20 528

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