Use of halogenated hydroxydiphenyl ether compounds for the treatment of the skin
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United States of America Patent
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Issued Date -
Sep 28, 2006
app pub date -
Jul 7, 2004
filing date -
Jul 16, 2003
priority date (Note) -
Abandoned
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Abstract
The use of hydroxydiphenyl ether compounds of formula (I), wherein R.sub.1, R.sub.2 and R.sub.3 are each independently of the others hydrogen; hydroxy; C.sub.1-C.sub.20alkyl; hydroxy-substituted C.sub.1-C.sub.20alkyl; C.sub.5-C.sub.7cycloalkyl; C.sub.1-C.sub.20alkoxy; C.sub.1-C.sub.6alkylcarbonyl; phenyl; or phenyl-C.sub.1-C.sub.3alkyl; R.sub.4 is hydrogen, C.sub.1-C.sub.20alkyl; hydroxy-substituted C.sub.1-C.sub.20alkyl; C.sub.5-C.sub.7cycloalkyl; hydroxy; formyl; acetonyl; allyl; carboxy; carboxy-C.sub.1-C.sub.3alkyl; carboxyallyl; C.sub.2-C.sub.20alkenyl; C.sub.1-C.sub.6alkylcarbonyl; C.sub.1-C.sub.3alkylcarbonyl-C.sub.1-C.sub.3alkyl; phenyl; or phenyl-C.sub.1-C.sub.3alkyl; and R.sub.5 is hydrogen; C.sub.1-C.sub.20alkoxy; or C.sub.1-C.sub.6alkylcarbonyl; as melanogenesis inhibitors and for lightening the skin.
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