Formulation of a mixture of Free-B-Ring flavonoids and flavans as a therapeutic agent
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United States of America Patent
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Issued Date -
Sep 14, 2006
app pub date -
Mar 10, 2006
filing date -
Mar 10, 2005
priority date (Note) -
Abandoned
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Abstract
The present invention provides a composition of matter comprised of a mixture of two specific classes of compounds--Free-B-Ring flavonoids and flavans--referred to herein as UP736 for use in the prevention and treatment of diseases and conditions related to platelet aggregation and platelet-induced thrombosis. The invention further provides a novel composition of matter comprised of UP736 in combination with injectable or oral anticoagulants, antiplatelet agents, non-steroidal anti-inflammatory drugs (NSAIDs) and COX-2 selective inhibitors and a method for using said composition in the prevention and treatment of diseases and conditions related to platelet aggregation and platelet-induced thrombosis. Finally, this invention provides a method for using UP736 in combination with anti-platelet, anti-coagulant, prophylaxis agents and NSAIDs as a means for reducing the dosage of these agents, decreasing the side effects associated with acute or chronic administration of these agents; counteracting or antagonizing the risks of acute or chronic administration of these agents and for achieving additional and/or multiple clinical benefits.
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