Process for preparing an alpha-1-antitrypsin solution
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United States of America Patent
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Issued Date -
Aug 31, 2006
app pub date -
Aug 12, 2004
filing date -
Aug 12, 2003
priority date (Note) -
Abandoned
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Abstract
A process for preparing A1AT from A1AT-containing solutions, comprising the following steps: (a) subjecting an A1AT-containing solution to ion-exchange chromatography; (b) adding detergents and optionally a solvent for inactivating lipid-enveloped viruses; (c) followed by increasing the salt concentration to salt out the detergents. A1AT having a purity of >90% with an activity of .gtoreq.0.8 PEU/mg in its active form.
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