Antiviral bifunctional molecules, methods of construction and methods of treating virus-induced cancer therewith
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United States of America Patent
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app pub date -
Jan 17, 2006
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Dec 10, 2004
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Abstract
The present invention relates to molecules that are capable of killing cells. The molecules comprise a targeting agent and a channel-forming moiety. The molecules may be polypeptides. The present invention also relates to polynucleotide sequences encoding the polypeptides of the invention. In a preferred embodiment, the channel-forming moiety comprises a colicin and the targeting agent is an antibody. Methods of treatment by administering the molecules of the present invention are also provided.
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