Genetic markers in the HLA-C gene associated with an adverse hematological response to drugs
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United States of America Patent
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Issued Date -
Aug 17, 2006
app pub date -
Feb 10, 2006
filing date -
Feb 11, 2005
priority date (Note) -
Abandoned
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Abstract
Genetic markers in the HLA-C gene associated with adverse hematological response to drug therapy are disclosed. Compositions and methods for detecting and using these HLA-C markers in a variety of clinical applications are disclosed. Such applications include methods for testing an individual for susceptibility for an adverse hematological response, methods of selecting the appropriate drug therapy for patients based on the presence or absence of a HLA-C marker, and products comprising a drug with hematological toxicity that are approved for treating patients lacking a genetic marker.
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