Transducible dna-binding proteins
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United States of America Patent
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Issued Date -
Aug 17, 2006
app pub date -
Jun 10, 2004
filing date -
Jun 10, 2003
priority date (Note) -
Abandoned
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Abstract
Disclosed is a chimeric protein comprising: a) a plurality of zinc finger domains; and b) a heterologous protein transduction domain, effective for translocating the protein across a cellular membrane. The chimeric protein can be efficiently transduced into cultured eukaryotic cells in which they regulate specific target genes. Thus, artificial transcription factors that include a PTD can be used to produce protein drugs that regulate endogenous genes and protein drugs that alter cell behavior in vitro and in vivo.
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