Methods and compositions for correcting misincorporation in a nucleic acid synthesis reaction
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United States of America Patent
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Issued Date -
Aug 3, 2006
app pub date -
Jan 5, 2006
filing date -
Jan 5, 2005
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Abandoned
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Abstract
The invention provides methods for correcting misincorporation of a nucleotide in a primer during a sequencing-by-synthesis reaction by using both a polymerase substantially lacking in exonuclease activity and an enzyme, preferably a polymerase, having exonuclease activity.
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