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Abstract

Methods of using a compound, its pharmaceutically acceptable salts, and/or its pro-drug esters, in isolated form, to treat cancer, and methods for isolating, for formulating, and for administering the compound, salt, and/or pro-drug ester as an antitumor agent, wherein the compound, salt, or pro-drug ester has the following structure: wherein: R.sub.1, R.sub.2, R.sub.5, R.sub.7, and R.sub.8 are each separately selected from the group consisting of a hydrogen atom, a halogen atom, and saturated C.sub.1-C.sub.24 alkyl, unsaturated C.sub.1-C.sub.24 alkenyl, cycloalkyl, cycloalkenyl, alkoxy, cycloalkoxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, amino, substituted amino, nitro, substituted nitro, phenyl, and substituted phenyl groups, R.sub.3, R.sub.4, and R.sub.6 are each separately selected from the group consisting of a hydrogen atom, a halogen atom, and saturated C.sub.1-C.sub.12 alkyl, unsaturated C.sub.1-C.sub.12 alkenyl, cycloalkyl, alkoxy, cycloalkoxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, amino, substituted amino, nitro, and substituted nitro groups, X.sub.1 and X.sub.2 are separately selected from the group consisting of an oxygen atom, and a sulfur atom, and the dashed bond represents a bond selected from the group consisting of a carbon-carbon single bond and a carbon-carbon double bond. Most preferably, R.sub.3 and R.sub.4 are hydrogen, and each are involved in hydrogen bonds, and/or the dashed bond is a double bond, such that the chemical backbone of the compound substantially retains a substantially planar conformation.

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First Claim