Production process for 16-dehydropregnenoneol and its analogs

Number of patents in Portfolio can not be more than 2000

United States of America Patent

APP PUB NO 20060166955A1
SERIAL NO

10561164

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Abstract

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The present invention relates to a clean process for the degradation of steroidal sapogenin to produce 16-dehydropregnenolone and its analogs. The pure or the crude pseudo steroidal sapogenin, derived from steroidal sapogenin, dissolved in organic solvent, reacts with hydrogen peroxide with or without metal compound and acid as catalyst, and the crude products directly go through elimination and hydrolization in the presence of base to give 16-Dehydropregnenolone or its analog, accompanied with the other product 4R(or S)-methyl-5-hydroxy-pentate, which is converted to 4R(or S)-methyl-.delta.-pentyl lactone after acidification and extraction from the water layer. This technology improved the utilizing degree of steroidal sapogenin, improved the yield, and cleared up the chromium pollution in the former technique. In a word, the method disclosed in this invention is more suitable for manufacture.

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Patent Owner(s)

Patent OwnerAddress
SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY CHINESE ACADEMY OF SCIENCESNO 345 LINGLING ROAD XUHUI DISTRICT SHANGHAI 200030

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Liu, Shanshan Shanghai, CN 51 70
Shen, Junwei Shanghai, CN 3 0
Tian, Weisheng Shanghai, CN 1 0
Wu, Xiujing Shanghai, CN 1 0
Xu, Xin Shanghai, CN 280 1735

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