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United States of America Patent
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N/A
Issued Date -
Jul 27, 2006
app pub date -
Jun 19, 2002
filing date -
Jun 20, 2001
priority date (Note) -
Abandoned
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Abstract
The present invention provides a multimers of class I Major Histocompatibility Complexes (MHCs) having a modified P2-microglobulin whose binding to CD8 is inhibited. Such MHCs are capable of inhibiting CD8.sup.+ T cell response, particularly by inducing apoptosis or anergy of the T cell. The invention also provides nucleic acids encoding such molecules, and the use of such multimers and nucleic acids in immunosuppressive therapy, in particular as inhibitors of cytotoxic T cell responses.
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