Mammalian grainyhead transcription factors
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United States of America Patent
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Aug 5, 2008
Grant Date -
Jul 20, 2006
app pub date -
Aug 8, 2003
filing date -
Aug 9, 2002
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention provides mammalian homologs of the Drosophila Grainyhead (GRH) transcription factor, call MGR and means of identifying such proteins and their genes. Nucleic acid and protein sequences are provided for human and mouse MGR transcription factors. In addition mammalian isoforms of MGR including human MGR p49, human p70, mouse p70, mouse MGR p61, and human and mouse homologs of MGR, brother of mgr (BOM) and sister of mgr (SOM), are disclosed. Antibodies to and methods of using these identified MGR, BOM and SOM transcription factors are also provided. The present invention further provides medical assessment systems including drug evaluation systems comprising genetically modified animals.
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