Zebrafish heterotrimer G-protein gamma 2 subunit (GNG2)
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United States of America Patent
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Issued Date -
Jul 13, 2006
app pub date -
Dec 28, 2005
filing date -
Dec 29, 2004
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Abandoned
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Abstract
The invention provides sequences of the zebrafish heterotrimeric G-protein gamma 2 subunit (GNG2). The invention also provides methods of inhibiting and promoting GNG2-dependent angiogenesis in vertebrates, particular mammals, including humans, for the treatment of angiogenesis-related diseases. The invention also provides methods of identifying compounds that promote or inhibit angiogenesis through their interaction with GNG2. The invention further provides methods of modulating angiogenesis through the modulation of both GNG2 and VEGF.
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