Engineering redox proteins

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United States of America Patent

APP PUB NO 20060148026A1
SERIAL NO

10537612

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The protein of this invention comprises a 4-.alpha.-helix bundle motif formed from the .alpha.-helices of rop (repressor of primer) and a redox centre. In this invention the redox centre is preferably haem and the iron is preferably coordinated to the .alpha.-helices of the rop structure via histidine residues. Such a protein is very stable and has the same specific activities as natural redox proteins with the increased stability in the interaction with electrode surfaces. Also provided by this invention is a method of engineering proteins to develop redox proteins from structures which previously had no redox functions.

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Patent Owner(s)

Patent OwnerAddress
NANOBIODESIGN LIMITED30A THAYER STREET LONDON W1U 2QP

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gilardi, Gianfranco London, GB 7 12

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