Methods of screening for modulators of nerve growth factor

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United States of America Patent

APP PUB NO 20060147932A1
SERIAL NO

10542184

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention relates, in general, to a method of screening for agents that modulate NGF activity. More specifically this invention provides a method of assessing the ability of a candidate agent to modulate NGF activity comprising, measuring the level of expression of one or more or two or more NGF responsive genes in a culture of neurons expressing the high-affinity trk A receptor after contact with a candidate agent. The invention further provides methods of culturing primary cultures of neurons expressing the high-affinity trk A receptor and methods of isolating polynucleotides from such cultures.

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Patent Owner(s)

Patent OwnerAddress
RINAT NEUROSCIENCE CORP66 HUDSON BOULEVARD EAST LEGAL PATENT DEPT CHIEF IP COUNSEL NEW YORK NY 10001-2192

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Davies, Alun St. Andrews, GB 1 19
Grimm, Jan Markus Menlo Park, CA 6 145
Wyatt, Sean Mountain View, CA 2 25

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