Methods for detection of promoter polymorphism in a UGT gene promoter
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United States of America Patent
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Issued Date -
Aug 14, 2003
app pub date -
Oct 21, 2002
filing date -
Feb 16, 1999
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Abandoned
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Abstract
The present invention is directed to methods for detecting the presence of genetic polymorphisms that correlate with altered gene expression. More specifically, the present invention is directed to methods for detecting the genetic polymorphisms located in the UGT1A1 promoter. The invention also provides methods for optimizing drug dosages based upon the presence of the polymorphisms. The invention further provides methods of predicting sensitivity to xenobiotics and diagnostic kits for detecting genetic polymorphisms.
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