3-(Carbonyl) 1h-indazole compounds as cyclin dependent kinases (cdk) inhibitors
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United States of America Patent
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Issued Date -
Jun 22, 2006
app pub date -
Aug 8, 2003
filing date -
Aug 10, 2002
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Abandoned
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Abstract
The invention provides a compound of the formula (I): wherein E is O, S, or NH; G is selected from hydrogen; carbocyclic and heterocyclic groups having from 3 to 12 ring members; and acyclic C.sub.1-8 hydrocarbyl groups optionally substituted; provided that E--G is not OH or SH and further provided that E--G does not contain the group O--O; two adjacent moieties selected from R.sup.3, R.sup.4, R.sup.5 and R.sup.6, together with the carbon atoms to which they are attached, form a fused heterocyclic group having from 5 to 7 ring members and 1, 2 or 3 ring heteroatoms selected from N, O and S; and the other two moieties selected from R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are the same or different and are each as defined in the description. The Invention also provides compounds of the formula (I) for use as inhibitors of cyclin dependent kinases and for use in the treatment of disease states and conditions mediated by cyclin dependent kinases.
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