Use of RNA trans-splicing for generation of interfering RNA molecules
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United States of America Patent
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Issued Date -
Jun 22, 2006
app pub date -
Aug 9, 2005
filing date -
Aug 9, 2004
priority date (Note) -
Abandoned
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Abstract
Methods and compositions for generating novel nucleic acid molecules through trans-splicing that function to reduce the level of expression of a target RNA. The compositions of the invention include pre-trans-splicing molecules (PTMs) designed to interact with a target precursor messenger RNA molecule (target pre-mRNA) and mediate a trans-splicing reaction resulting in the generation of primary microRNAs (pri-miRNAs), which are processed in the cell to molecules, referred to as mature miRNA duplex or short interfering RNAs (siRNAs), capable of producing gene silencing by RNA interference (RNAi).
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