Production of heterologous proteins in Caulobacter
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United States of America Patent
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Issued Date -
Jun 8, 2006
app pub date -
Nov 21, 2005
filing date -
Nov 23, 2004
priority date (Note) -
Abandoned
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Abstract
The present invention has identified the Caulobacter RsaFa and RsaFb proteins as the OMP components of the S-layer protein secretion machinery. The present invention has also identified that an enhanced production of a heterologous protein from Caulobacter can be achieved by increased production of RsaFa and/or RsaFb. Expression vectors, genetically engineered Caulobacter strains, as well as methods are provided that are useful for producing a heterologous protein in Caulobacter.
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