Heat shock fusion-based vaccine system

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United States of America Patent

APP PUB NO 20060121051A1
SERIAL NO

11225687

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Disclosed are self-epitope-containing heat shock fusion proteins, DNA constructs encoding such fusion proteins, and methods of use. More specifically, disclosed are ubiquitin fusion proteins comprising ubiquitin fused to a plurality of identical or non-identical self-epitopes at specified locations. Immunization of an animal with these ubiquitin fusion proteins elicits an immune response to self-antigens present on endogenous proteins. Generation of an immune response to a specified self-antigen is a mechanism to decrease the levels of the endogenous protein below base-line.

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Patent OwnerAddress
WELLSTAT BIOCATALYSIS LLC930 CLOPPER ROAD GAITHERSBURG MD 20878

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kenten, John Henry Boyds, MD 6 143
Lohnas, Gerald Mt. Airey, MD 6 39
Roberts, Steven Bethesda, MD 12 53

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