Halothenoyl-cyclopropane-1-carboxylic acid derivatives
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United States of America Patent
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Issued Date -
Jun 1, 2006
app pub date -
Nov 25, 2003
filing date -
Nov 28, 2002
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Abandoned
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Abstract
Compounds of formula (I) wherein R is hydroxy, linear or branched C.sub.1-C.sub.6 alkoxy, phenoxy, benzyloxy, a group --N(R.sup.1R.sup.2) wherein R.sup.1 is hydrogen, linear or branched C.sub.1-C.sub.4 alkyl, benzyl, phenyl and R.sup.2 is hydrogen or linear or branched C.sub.1-C.sub.4 alkyl, or R is a glycoside residue or a primary alkoxy residue from ascorbic acid, optionally having one or more hydroxy groups alkylated or acylated by linear or branched C.sub.1-C.sub.4 alkyl or acyl groups; X is a halogen atom and n 1 or 2 are long lasting inhibitors of kynurenine 3-monooxygenase (KMO) and potent glutamate (GLU) release inhibitors.
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