Recombinant BCG strains with attenuated immunosuppressive properties
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United States of America Patent
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Issued Date -
Jun 1, 2006
app pub date -
Nov 23, 2005
filing date -
Dec 1, 2004
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Abstract
Strains of Mycobacterium that have decreased immunosuppressive properties are provided. The Mycobacterium strains are genetically engineered to express but not secrete super-oxide dismutase (Sod). The presence of cytosol bound Sod allows replication and growth of the Mycobacterium, but does not result in attenuation of the host immune response. The Mycobacterium strains provide improved properties for use as vaccines.
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