Method of imaging cell death in vivo
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United States of America Patent
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Issued Date -
May 25, 2006
app pub date -
Nov 17, 2005
filing date -
Nov 19, 2004
priority date (Note) -
Abandoned
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Abstract
The present invention relates to a method and a kit for detecting cell death or another condition characterized by an increase in the extracellular level of phosphatidylserine in a mammalian subject. The method involves administering a radionuclide-labeled compound that comprises a C2 domain of a protein or an active variant thereof and measuring radiation emission from the radionuclide in the subject to obtain an image of radiation emission, wherein the site of cell death or said condition can be determined from the image. The kit can contain a radionuclide-labeled compound comprising a C2 domain or an active variant thereof and an instruction on administering the compound into a mammalian subject to image cell death or said condition.
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