Methods of Tranducing genes into T cells
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United States of America Patent
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Issued Date -
May 18, 2006
app pub date -
Oct 22, 2003
filing date -
Oct 24, 2002
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Abandoned
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Abstract
The present invention provides methods of transducing a gene into activated T cells comprising the step of contacting a paramyxovirus vector with activated T cells. This invention also provides a method of preparing T cells transduced with a foreign gene comprising the step of contacting a paramyxovirus vector with activated T cells. This invention also provides T cells transduced with a foreign gene prepared by this method. The present invention enables efficient gene transduction specific to activated T cells, and is expected to be applied to immunological modification strategies using T cell-directed gene delivery.
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