Method of preselection patients for anti-VEGF, anti-HIF-1 or anti-thioredoxin therapy
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United States of America Patent
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Issued Date -
May 18, 2006
app pub date -
Aug 17, 2005
filing date -
Aug 17, 2004
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Abstract
The present invention generally relates to methods of preselecting patients for treatment with an anti-VEGF therapy, anti-HIF-1 therapy or anti-thioredoxin therapy. Aspects of the invention combine methods of dynamic contrast enhanced-MRI and diffusion weighted-MRI for the detection of tumor histology. The methodology disclosed herein detects tissue blood volume, tumor vascularity, and abnormal capillary permeability, thereby determining tumor vascularity to determine whether a patient should be administered such therapy.
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