Methods and compositions for determining resistance or susceptibility of HIV-1 to stavudine
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United States of America Patent
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Issued Date -
May 4, 2006
app pub date -
Oct 29, 2004
filing date -
Oct 29, 2004
priority date (Note) -
Abandoned
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Abstract
This invention relates to methods for determining resistance or susceptibility of HIV-1 viruses to d4T based on the viral genotypes. The methods generally comprise detecting, in a gene encoding reverse transcriptase of the HIV-1, the presence of a mutation at codon 65 in combination with one or more mutations at certain other codons. Combinations of mutations associated with resistance and susceptibility to d4T are disclosed.
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