Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase
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United States of America Patent
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app pub date -
Oct 28, 2005
filing date -
Apr 29, 2004
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Abstract
The present invention provides compositions of matter, kits and methods for their use in the treatment of MAP kinase-related conditions and/or HMG-CoA reductase-related conditions. In particular, the invention provides compositions for treating inflammatory and/or cardiovascular conditions in an animal subject by inhibiting p38.alpha. MAP kinase and/or HMG-CoA reductase, as well as providing formulations and modes of administering such compositions. The invention further provides methods for the rational design of inhibitors of MAP kinase, HMG-CoA reductase, or both for use in the practice of the present invention.
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