Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and protein kinase (serine/threonine kinase) inhibitors
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United States of America Patent
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Issued Date -
Apr 20, 2006
app pub date -
Dec 18, 2002
filing date -
Jan 2, 2002
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Abstract
The present invention provides the combined use of acryloyl distamycin derivatives, in particular .alpha.-bromo- and .alpha.-chloro-acryloyl distamycin derivatives of formula (I), as set forth in the specification, and a protein kinase (serine/threonine and tyrosine kinases) inhibitor, in the treatment of tumors. Also provided is the use of the said combinations in the treatment or prevention of metastasis or in the treatment of tumors by inhibition of angiogenesis.
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