Peptide boronic acid inhibitors
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United States of America Patent
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app pub date -
Mar 9, 2005
filing date -
Sep 9, 2002
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Abstract
A pharmaceutically acceptable base addition salt of an organoboronic acid of formula (XXX): wherein: P is hydrogen or an amino-group protecting moiety; R is hydrogen or alkyl; A is 0, 1 or 2; R.sup.1, R.sup.2 and R.sup.3 are independently hydrogen, alkyl, cycloalkyl, aryl or --CH.sub.2--R.sup.5; R.sup.5, in each instance, is one of aryl, aralkyl, alkaryl, cycloalkyl, heterocyclyl, heteroaryl, or --W--R.sup.6, where W is a chalcogen and R.sup.6 is alkyl; and where the ring portion of any of said aryl, aralkyl, alkaryl, cycloalkyl, heterocyclyl, or heteroaryl in R.sup.1, R.sup.2, R.sup.3 or R.sup.5 can be optionally substituted.
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