Thermoreversible pharmaceutical formulation for anti-microbial agents comprising poloxamer polymers and hydroxy fatty acid ester of polyethylene glycol
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United States of America Patent
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Issued Date -
Apr 13, 2006
app pub date -
Aug 16, 2005
filing date -
Aug 30, 2004
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Abandoned
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Abstract
The present invention provides a pharmaceutical formulation having thermoreversible properties, comprising: a) an anti-microbial agent; b) a poloxamer mixture containing at least two poloxamer polymers; and c) a hydroxy fatty acid ester of polyethylene glycol, wherein the formulation is a solid at room temperature and is a liquid-gel at body temperature. The thermoreversible pharmaceutical formulation has a viscosity of about 8,500 cP to about 400,000 cP at room temperature, and a viscosity of about 1,000 cP to about 8,000 cP at body temperature and exhibits a hysteresis loop behavior. The present invention further provides a process of preparing as well as a method of treating a microbial infection in a mammal using the same.
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