Dinucleotide inhibitors of de novo RNA polymerases for treatment or prevention of viral infections
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United States of America Patent
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Apr 6, 2006
app pub date -
Apr 17, 2003
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Apr 17, 2002
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Abstract
Contemplated dinucleotide compounds have a general structure of A-B and inhibit synthesis of an RNA-dependent polymerase that initiates RNA replication de novo. In preferred dinucleotides, A comprises a purine or modified purine heterocyclic base and B comprises a pyrimidine or modified pyrimidine heterocyclic base.
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