Irreversible caspase-3 inhibitors as active site probes
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United States of America Patent
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Issued Date -
Mar 30, 2006
app pub date -
Feb 5, 2004
filing date -
Feb 7, 2003
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Abandoned
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Abstract
The present invention encompasses a compound of Formula (I) useful as caspase active site probes. These probes can be used to determine whether a caspase has been activated, in cells or in tissues of animal models of various pathologies. Furthermore, through competition based assays, these caspase active site probes can be used to calculate the percentage of occupancy of active caspases by other, unlabeled inhibitors.
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