Method and device for diagnosing and treating insulin-like growth factor deficiency disorders
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United States of America Patent
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Jan 31, 2012
Grant Date -
Mar 23, 2006
app pub date -
Aug 29, 2005
filing date -
Aug 30, 2004
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Abstract
The present invention provides standard deviation score (SDS) calculators, which SDS calculators are useful for transforming insulin-like growth factor-1 (IGF-1) concentrations to IGF-1 standard deviation scores. In one embodiment, IGF-1 blood levels are calculated so as to take into account IGFBP-3 blood levels (and, optionally, IGF-2 blood levels) to provide an IGF-1 production rate, which can be used to calculate an IGF-1 production rate SDS. The IGF-1 SDS and IGF-1 production rate SDS are particularly useful in assessing the stimulated rate of IGF-1 production in response to, for example, growth hormone therapy.
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