Compositions for the delivery of therapeutic agents and uses thereof
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United States of America Patent
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Issued Date -
Mar 9, 2006
app pub date -
Jul 19, 2005
filing date -
Jul 19, 2004
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Abstract
The present invention provides drug delivery vehicles comprising polytheylyene-lipid conjugates (PEG-lipid), wherein the circulation lifetime and biodistribution of the drug delivery vehicles are regulated by the PEG-lipid. More particularly, the present invention provides liposomes, SNALP and SPLP comprising such PEG-lipid conjugates, and methods of using such compositions to selectively target a tumor site or other tissue of interest (e.g., liver, lung, spleen, etc.).
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