Methods and kits for determining metabolic stability of compounds
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United States of America Patent
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Issued Date -
Mar 2, 2006
app pub date -
Aug 26, 2004
filing date -
Aug 26, 2004
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Abstract
The present invention provides methods and kits for determining the metabolic stability of compounds (e.g., stability to oxidative metabolism). In particular embodiments, the invention provides a method of determining the susceptibility of a compound to metabolism by an enzyme. In one representative embodiment, the enzyme is a cytochrome P450 enzyme. The invention is well-adapted for use in high throughput drug screening programs.
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