Synthesis of a mixture of sulfated estrogens using a sulfur trioxide complex
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United States of America Patent
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Issued Date -
Feb 23, 2006
app pub date -
Oct 26, 2005
filing date -
Jan 8, 2002
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Abandoned
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Abstract
A process of producing a stable composition comprising a mixture of sulfated estrogens. The mixture of sulfated estrogens may comprise sulfated alkali metal salts of .DELTA..sup.8,9-dehydroestrone, estrone, and derivatives thereof or other estrogens. The process comprises the steps of sulfating such mixture of alkali metal salts of .DELTA..sup.8,9-dehydroestrone, estrone, and derivatives thereof with a sulfur trioxide complex and adding tris(hydroxymethyl)aminomethane.
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