Use of the protein maba (fabg1) of mycobacterium tuberculosis for designing and screening antibiotics
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United States of America Patent
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Issued Date -
Feb 16, 2006
app pub date -
Mar 28, 2003
filing date -
Mar 29, 2002
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Abstract
The invention especially relates to the protein MabA, also named protein FabG1, which is recombinant in a purified form, or the recombinant proteins derived from the protein MabA by mutation of at least one amino acid. The invention also relates to the uses of said proteins and to the crystallographic co-ordinates thereof, in terms of the implementation of methods for designing and screening ligands of said proteins, and advantageously, ligands inhibiting the enzymatic activity of said proteins.
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