Growth hormone releasing hormone enhances vaccination response
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United States of America Patent
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Issued Date -
Feb 2, 2006
app pub date -
Jul 21, 2005
filing date -
Jul 23, 2004
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Abstract
This invention discloses compositions and methods of: vaccinating a subject; enhancing the vaccination efficiency; preparing a subject prior to vaccination response; and improving the clinical outcome after infectious challenge in a subject that has been vaccinated. More specifically, the invention pertains to delivering into a tissue of the subject a nucleic acid expression construct that encodes a growth-hormone-releasing-hormone ('GHRH') before or concomitantly with delivering a vaccine to the subject, wherein, GHRH is expressed in vivo in the subject, wherein the subject comprises a human, pig, cow, bird, horse or any other animal species receiving a vaccine.
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