Hybrid molecules QA, wherein Q is an aminoquinoline and a is an antibiotic or a resistance enzyme inhibitor, their synthesis and their uses as antibacterial agent

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United States of America Patent

APP PUB NO 20060025327A1
SERIAL NO

11019450

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Aminoquinoline-antibiotic hybrid compounds in the form of hybrid molecules QA, wherein Q is an aminoquinoline and A is an antibiotic or a resistance enzyme inhibitor, their synthesis and their uses as antibacterial agent. This compound is defined by the general formula (I): Q-(Y.sub.1).sub.p--(U).sub.p'--(Y.sub.2).sub.p''-A (I) in which Q represents an aminoquinoline, (Y.sub.1).sub.p--(U).sub.p'--(Y.sub.2).sub.-p''-- is an optional spacer arm and A is an antibiotic, one of its derivatives or precursors, or a resistance enzyme inhibitor. The invention unexpectedly enables the activity of the antibiotic to be improved.

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Patent Owner(s)

Patent OwnerAddress
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)3 RUE MICHEL ANGE PARIS F-75016
PALUMED S A31320 CASTANET-TOLOSAN

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Meunier, Bernard Castanet-Tolosan, FR 24 193
Sanchez, Muriel Balma, FR 2 25

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