Modulation of stem cell differentiation by modulation of caspase-3 activity
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United States of America Patent
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Issued Date -
Jan 19, 2006
app pub date -
Jul 22, 2005
filing date -
Dec 10, 2002
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Abstract
Methods of directing stem cell fate for therapeutic purposes through the deliberate manipulation of caspase-3 activity are provided. The use of modulators of caspase-3 activity to modulate stem cell differentiation is described including activators and/or effectors of caspase-3, which can be used to induce stem cell differentiation, and inhibitors of caspase-3, which can be used to inhibit differentiation and thereby promote or maintain proliferation of stem cells. Methods of screening for modulators of caspase-3 and the use of such compounds to modulate stem cell differentiation in vitro or in vivo are also provided as are therapeutic applications of the compounds.
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