Hydroxamic acids and acyl hydroxamines as NAALADase inhibitors
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United States of America Patent
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Issued Date -
Jan 12, 2006
app pub date -
Mar 1, 2005
filing date -
May 11, 2001
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Abstract
This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-.beta. activity, inhibiting angiogenesis, and treating glutamate abnormalities, neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.
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