Prodrugs of HIV replication inhibiting pyrimidines
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United States of America Patent
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Jul 27, 2010
Grant Date -
Jan 12, 2006
app pub date -
Sep 13, 2005
filing date -
May 8, 2000
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Abstract
The present invention concerns compounds of formula (A.sub.1)(A.sub.2)N--R.sup.1 (I), the N-oxide forms, the pharmaceutically acceptable addition salts, the quaternary amines and stereochemically isomeric forms thereof, wherein R.sup.1 is substituted C.sub.1-6alkyl; --S(.dbd.O)--R.sup.8; --S(.dbd.O).sub.2--R.sup.8; C.sub.7-12alkylcarbonyl; optionally substituted C.sub.1-6alkyloxycarbonylC.sub.1-6alkylcarbonyl; with R.sup.8 being C.sub.1-6alkyl, aryl.sup.1 or Het.sup.1; (A.sub.1)(A.sub.2)N-- is the covalently bonded form of the corresponding intermediate of formula (A.sub.1)(A.sub.2)N--H, which is a HIV replication inhibiting pyrimidine of formula ##STR00001##
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