Stable liquid and lyophilized formulation of proteins
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United States of America Patent
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Issued Date -
Jan 12, 2006
app pub date -
Jun 24, 2005
filing date -
Jun 25, 2004
priority date (Note) -
Abandoned
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Abstract
The present invention is directed to stable protein derivatives, e.g., antibodies, antibody fragments or peptides, with at least one free thiol group coupled to N-acetyl-L-cysteine, N-ethyl-maleimide, or cysteine and the methods of making such derivatives. In addition, stable liquid pharmaceutical formulations comprising such proteins or their derivatives and stable lyophilized pharmaceutical formulations comprising such proteins are provided. The present invention is also directed to a method of making a stable Fab' fragment of an antibody and a method of controlling vascularization in injured or cancerous tissue comprising applying to the injured tissue one or more doses of the pharmaceutical formulations.
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