Peptide antibiotics and peptide intermediates for their prepartion
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United States of America Patent
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Issued Date -
Jan 5, 2006
app pub date -
Jul 1, 2004
filing date -
Jul 1, 2004
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Abstract
Novel protected cyclopeptide intermediates are prepared from polymyxin B are used to synthesize new peptide antibiotics. Intermediates are readily derivatized and deprotected to provide new families of antibiotics, which have potent anti-bacterial activity against gram-negative bacteria; but also are useful and potent against gram-positive bacteria.
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