Methods and compositions for identification of antigen-specific B cell populations
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United States of America Patent
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Issued Date -
Dec 29, 2005
app pub date -
Jan 4, 2005
filing date -
Jan 7, 2004
priority date (Note) -
Abandoned
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Abstract
Provided are compositions and methods for identifying, enumerating and isolating B cells that react to a particular antigen. Included are tetrameric antigen-avidin complexes not comprising an MHC molecule, kits for producing the complexes, and reagents for diagnosing an autoimmune disease or monitoring progression of an autoimmune disease comprising the complexes. Also provided are B cells comprising the complexes and methods of using the complexes for: labeling a B cell reactive to a specific antigen, isolating a B cell reactive to a specific antigen from a mixture of B cells reactive to more than one antigen, quantifying B cells reactive to a specific antigen in a mixture of B cells reactive to more than one antigen, measuring immunity in a mammal characterized by the presence of B cells reactive to a specific antigen, and monitoring a disease in a mammal or determining whether a mammal has a disease characterized by the presence of B cells reactive to a specific antigen.
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