Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
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United States of America Patent
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Issued Date -
Dec 29, 2005
app pub date -
Jun 22, 2005
filing date -
Nov 9, 2001
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Abandoned
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Abstract
A method provides an index that is indicative of the state of a subject, as to a biological condition, based on a sample from the subject. An embodiment of this method includes: deriving from the sample a profile data set, the profile data set including a plurality of members, each member being a quantitative measure of the amount of a distinct RNA or protein constituent in a panel of constituents selected so that measurement of the constituents enables evaluation of the biological condition; and in deriving the profile data set, achieving such measure for each constituent under measurement conditions that are substantially repeatable; and applying values from the profile data set to an index function that provides a mapping from an instance of a profile data set into a single-valued measure of biological condition, so as to produce an index pertinent to the biological condition of the subject.
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