Process for the synthesis of thalidomide
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United States of America Patent
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Issued Date -
Dec 8, 2005
app pub date -
May 31, 2005
filing date -
Jun 1, 2004
priority date (Note) -
Abandoned
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Abstract
The invention relates to a process for the preparation of thalidomide (I) 1 comprising the reaction between glutamine (II) 2 and a phthaloylating agent, preferably phthalic anhydride, to give N-phthaloyl-glutamine, which is directly transformed in thalidomide.
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