Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity
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United States of America Patent
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Issued Date -
Dec 8, 2005
app pub date -
Mar 25, 2005
filing date -
Mar 29, 1999
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Abandoned
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Abstract
The present invention provides peptide analogues which are antagonists of gastric inhibitory peptide (GIP). The peptides, based on GIP 1-42 include substitutions and/or modifications which have enhanced resistance to degradation by the enzyme dipeptidyl peptidase IV (DPP IV). The invention also provides a process of N terminally modifying GIP and the use of the peptide analogues for treatment of diabetes.
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