Biodegradable composition with prolonged release of the biological active compound and preparation thereof
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United States of America Patent
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Issued Date -
Dec 8, 2005
app pub date -
Feb 17, 2005
filing date -
Aug 22, 2002
priority date (Note) -
Abandoned
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Abstract
Biodegradable antitumor composition with prolonged release has at least one antitumor agent and a biodegradable oligoester carrier, having a numeric mean relative molecular mass M.sub.n of from 650 to 7,500, a mass mean relative molecular mass M.sub.w from 800 to 10,000 and a glass transition temperature T.sub.g from -35 to 45.degree. C. The carrier is prepared by polycondensation reaction of polyhydric alcohol containing at least 3 hydroxy groups with at least one aliphatic .alpha.-hydroxy acid in the molar ratio of polyhydric alcohol to aliphatic .alpha.-hydroxy acid of from 0.5:99.5 to 12:88, and is a polyhydric alcohol to the hydroxy groups of which chains created from several molecules of at least one aliphatic .alpha.-hydroxy acid are bound by ester bonds.
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