Polypeptides derived from inducible hsp70 and pharmaceutical compositions containing the same
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United States of America Patent
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Issued Date -
Dec 1, 2005
app pub date -
Jan 3, 2005
filing date -
Sep 27, 2001
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Abandoned
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Abstract
A peptide comprising an amino acid sequence of at least 8 contiguous amino acids, the amino acid sequence being at least 65% identical to a portion of the same length within the amino acid sequence of inducible Hsp70, characterized in that the peptide amino acid sequence differs from any amino acid sequence of the same length of the constitutive Hsc70 amino acid sequence by at least one amino acid, and that the peptide is able to induce in vitro or in vivo cytotoxic T lymphocytes able to specifically recognize cells naturally producing inducible Hsp70, the cytotoxic T lymphocytes being able to recognize bath mutated and non mutated Hsp70 epitopes but not Hsc70 epitopes
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